Un nuovo studio capovolge la teoria ben consolidata che gli anticorpi siano necessari per l’immunità antivirale.
L’immunità agli agenti patogeni dipende da una risposta complessa delle cellule del corpo che può – o non può – includere la produzione di anticorpi. Un test del titolo (anticorpale) misura tipicamente solo un aspetto della risposta del sistema immunitario, e non esiste un test per la misurazione qualitativa di queste cellule di memoria.
Sarebbe un disastro per Big Pharma se più persone sapessero la verità sul fatto che la conta degli anticorpi non ha nulla a che fare con la vera immunità. Dopo tutto, i vaccini di Big Pharma si basano esclusivamente sulla stimolazione artificiale di una risposta immunitaria (in particolare con adiuvanti tossici come l’alluminio) inducendo l’organismo a produrre anticorpi.
Dr. Antonio Miclavez
Antibodies are not required for immunity against some viruses
- March 1, 2012
- Cell Press
- A new study turns the well established theory that antibodies are required for antiviral immunity upside down and reveals that an unexpected partnership between the specific and non-specific divisions of the immune system is critical for fighting some types of viral infections. The research may lead to a new understanding of the best way to help protect those exposed to potentially lethal viruses, such as the rabies virus.
A new study turns the well established theory that antibodies are required for antiviral immunity upside down and reveals that an unexpected partnership between the specific and non-specific divisions of the immune system is critical for fighting some types of viral infections. The research, published online on March 1st in the journal Immunity by Cell Press, may lead to a new understanding of the best way to help protect those exposed to potentially lethal viruses, such as the rabies virus.
The immune system has two main branches, innate immunity and adaptive immunity. Innate immunity is a first line of defense that relies on cells and mechanisms that provide non-specific immunity. The more sophisticated adaptive immunity, which counts antibody-producing B cells as part of its arsenal, is thought to play a major role in the specific response to viral infections in mammals. However, adaptive immune responses require time to become fully mobilized.
“Mice infected with vesicular stomatitis virus (VSV) can suffer fatal invasion of the central nervous system even when they have a high concentration of anti-VSV antibodies in their system,” explains senior study author, Dr. Ulrich H. von Andrian, from Harvard Medical School. “This observation led us to revisit the contribution of adaptive immune responses to survival following VSV infection.”
The research team studied VSV infection in mice that had B cells but did not produce antibodies. Unexpectedly, although the B cells themselves were essential, survival after VSV exposure did not require antibodies or other aspects of traditional adaptive immunity.”We determined that the B cells produced a chemical needed to maintain innate immune cells called macrophages. The macrophages produced type I interferons, which were required to prevent fatal VSV invasion,” says co-author Dr. Matteo Iannacone.
Taken together, the results show that the essential role of B cells against VSV does not require adaptive mechanisms, but is instead directly linked with the innate immune system. “Our findings contradict the current view that antibodies are absolutely required to survive infection with viruses like VSV, and establish an unexpected function for B cells as custodians of macrophages in antiviral immunity,” concludes Dr. von Andrian. “It will be important to further dissect the role of antibodies and interferons in immunity against similar viruses that attack the nervous system, such as rabies, West Nile virus, and Encephalitis.”
Journal reference: Moseman et al.: “B Cell Maintenance of Subcapsular Sinus Macrophages Protects against a Fatal Viral Infection Independent of Adaptive Immunity.”
Materials provided by Cell Press. Note: Content may be edited for style and length.
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