lI ruolo putativo dell’ALLUMINIO ambientale nello sviluppo della NEUROPATOLOGIA CRONICA negli adulti e nei bambini. Quanto sono forti le prove e quali potrebbero essere i meccanismi coinvolti? – Gerwyn Morris, Basant K. Puri e Richard E. Frye – Metabolik Brain Disease – 27 Luglio 2017 – Corvelva

Il ruolo putativo dell’alluminio ambientale nello sviluppo della neuropatologia cronica negli adulti e nei bambini. Quanto sono forti le prove e quali potrebbero essere i meccanismi coinvolti?

In questa traduzione riportiamo solamente la PREMESSA, le CONCLUSIONI e i RIFERIMENTI.
Lasciamo a disposizione la consultazione dell’intero studio nei link in fondo alla pagina.

Metabolic Brain Disease
Gerwyn Morris 1, Basant K. Puri 2 e Richard E. Frye
1 Tir Na Nog, Bryn Road seaside 87, Llanelli, Wales
2 Department of Medicine, Imperial College London, Hammersmith Hospital, London, England
3 College of Medicine, Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children’s Hospital Research Institute, Little Rock
27 luglio 2017

Premessa
La concettualizzazione del disturbo dello spettro autistico e della malattia di Alzheimer ha subito un cambiamento paradigmatico negli ultimi anni e invece di essere viste come singole malattie con patogenesi unitaria e patofisiologia sono sempre più considerate sindromi eterogenee con una complessa eziopatogenesi multifattoriale, che coinvolge un combinazione complessa e diversificata di fattori genetici, epigenetici e ambientali. Uno di questi fattori ambientali implicati come causa potenziale in entrambe le sindromi è l’alluminio, come elemento o parte di un sale, ricevuto, per esempio, in forma orale o come adiuvante. Tale somministrazione ha il potenziale per indurre patologie attraverso diverse vie come provocare disfunzione e / o attivazione di cellule che svolgono un ruolo indispensabile nella regolazione dell’omeostasi e del neurosviluppo del sistema nervoso centrale. Altre vie includono la generazione di stress ossidativo, l’esaurimento del glutatione ridotto, riduzioni dirette e indirette delle prestazioni e dell’integrità mitocondriale e l’aumento della produzione di citochine proinfiammatorie sia nel cervello che in periferia. Vengono descritti i meccanismi attraverso i quali l’alluminio ambientale potrebbe contribuire allo sviluppo del modello altamente specifico di neuropatologia visto nella malattia di Alzheimer. Inoltre, sono dettagliati diversi meccanismi in base ai quali quantità significative di alluminio introdotte attraverso l’immunizzazione potrebbero produrre neuropatologia cronica in bambini geneticamente suscettibili. Di conseguenza, si raccomanda di interrompere l’uso di sali di alluminio nelle vaccinazioni e che gli adulti debbano adottare misure per ridurre al minimo la loro esposizione all’alluminio ambientale.

Conclusioni
L’alluminio non ha alcuna azione benefica fisiologica nota nel corpo umano e alcuni polimorfismi genetici predispongono a una maggiore suscettibilità ai suoi effetti avversi. Pertanto ci sono argomentazioni forti per evitare un’esposizione non necessaria a fonti ambientali di sali di alluminio, specialmente da parte di bambini, madri in gravidanza e donne in età fertile che possono iniziare una gravidanza. Evitarlo non deve portare a disagi; le pentole in alluminio possono essere sostituite da alternative più sicure, mentre gli antitraspiranti contenenti alluminio, potenzialmente implicati nell’aumento dei casi di cancro al seno che interessano in particolare il quadrante superiore esterno della ghiandola mammaria, possono essere sostituiti da versioni non in alluminio. L’uso di sali di alluminio nei prodotti medici è un problema più controverso. Mentre gli antiacidi sono disponibili che non contengono sali di alluminio, la prevenzione di vaccinazioni che non contengono sali di alluminio come adiuvanti ha implicazioni politiche e finanziarie più ampie. Sembrerebbe prudente cercare di trovare un’alternativa ai coadiuvanti di alluminio il prima possibile ed eliminarne gradualmente l’uso.

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Fonte: The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?
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