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[WITHDRAWN: Potential false-positive rate among the ‘asymptomatic infected individuals’ in close contacts of COVID-19 patients]
Zhuang GH, Shen MW, Zeng LX, Mi BB, Chen FY, Liu WJ, Pei LL, Qi X, Li C.
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Mar 5;41(4):485-488. doi: 10.3760/cma.j.cn112338-20200221-00144. Online ahead of print.
PMID: 32133832 Chinese.
However, the false-positive rate of positive results in the screening has not been reported up to now. But to clearify the false-positive rate during screening is important in COVID-19 control and prevention. …Conclusions: In the close contacts of COVID-19 patients, nearly half or even more of the ‘asymptomatic infected individuals’ reported in the active nucleic acid test screening might be false positives….
Routine blood tests as a potential diagnostic tool for COVID-19.
Ferrari D, Motta A, Strollo M, Banfi G, Locatelli M.
Clin Chem Lab Med. 2020 Apr 16:/j/cclm.ahead-of-print/cclm-2020-0398/cclm-2020-0398.xml. doi: 10.1515/cclm-2020-0398. Online ahead of print.
Objectives The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to date, the epidemic has gradually spread to 209 countries worldwide with more than 1.5 million infected people and 100,000 deaths. …Empirical thresholds for AST and LDH allowed the identification of 70% of either COVID-19-positive or -negative patients on the basis of routine blood test results. …
Potential false-negative nucleic acid testing results for Severe Acute Respiratory Syndrome Coronavirus 2 from thermal inactivation of samples with low viral loads.
Pan Y, Long L, Zhang D, Yan T, Cui S, Yang P, Wang Q, Ren S.
Clin Chem. 2020 Apr 4:hvaa091. doi: 10.1093/clinchem/hvaa091. Online ahead of print.
In some circumstances, thermal inactivation at 56 °C has been recommended to inactivate Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) before NAT. …We examined the effects of thermal inactivation on the quantitative RT-PCR results of SARS-CoV-2 particularly with regard to the rates of false-negative results for specimens carrying low viral loads. …
Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19).
Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, Dela Cruz CS, Wang Y, Wu C, Xiao Y, Zhang L, Han L, Dang S, Xu Y, Yang Q, Xu S, Zhu H, Xu Y, Jin Q, Sharma L, Wang L, Wang J.
Clin Infect Dis. 2020 Mar 21:ciaa310. doi: 10.1093/cid/ciaa310. Online ahead of print.
We here aim to describe the time kinetics of various antibodies produced against the 2019 novel coronavirus (SARS-CoV-2) and evaluate the potential of antibody testing to diagnose COVID-19. …CONCLUSIONS: Humoral response to SARS-CoV-2 can aid to the diagnosis of COVID-19, including subclinical cases….